Harmonia Mentis Norway
GUIDE to DRUG INTERACTIONS with CENOBAMATE
GUIDE to DRUG INTERACTIONS with CENOBAMATE
To provide an improved quality of life for individuals with epilepsy, the main objective of treatment is to optimize seizure regulation while minimizing the negative impacts of therapy on the patient's well-being.1
Specific guidelines regarding polytherapy do not exist. Theoretical proposals are frequently referred to as “rational polytherapy” 1
Lowering the dosage of the pre-existing ASM may prove to be a beneficial tactic when combining therapies, especially in cases where there is already a significant drug load1
In situations where adverse effects begin to emerge, certain experts recommend modifying the dosage of the current medication as opposed to decreasing the dose of the new ASM. Furthermore, it is always important to consider the pharmacokinetic and pharmacodynamic properties of each drug.1
Cenobamate has clinically relevant drug-drug interactions.1 The purpose of this tool is to assist you in your day-to-day clinical activities, allowing you to optimize the benefits of utilizing cenobamate as a treatment option while also improving safety and adherence to the treatment plan.
- Recommendation to reduce the dose of concomitant drugs
- No dosage adjustment required
- Recommendation to increase the dose of concomitant drugs
References
1. Schmitz B, Lattanzi S, Vonk K et al. Cenobamate in refractory epilepsy: Overview of treatment options and practical considerations. Epilepsia Open 2023 Dec;8(4):1241-1255
Where not differently specified, references used in cenobamate interaction guide are:
Flockhart DA, Thacker D, McDonald C, Desta Z. The Flockhart Cytochrome P450 Drug-Drug Interaction Table. Division of Clinical Pharmacology, Indiana University School of Medicine. https://drug-interactions.medicine.iu.edu/. Last accessed April 2024.
Ontozry Summary of Product Charasteristics: https://www.ema.europa.eu/en/documents/product-information/ontozry-epar-product-information_en.pdf. Last accessed April 2024.
Ontozry produktinformasjon:
https://www.harmoniamentis.no/ontozry-senobamat/
NO23554P May 2024